Retinol
Retinol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target nuclear receptor subfamily 2 group C member 2.
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Therapeutic Areas
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| a and d plus e | C200263 | 2024-08-08 |
| acne relief retinol treatment and moisturizer | OTC monograph final | 2022-02-10 |
| altra hand sanitizer with aloe and vitamin e | C200263 | 2024-07-23 |
| anyi beauty retinol brightening anti aging face cream | C200263 | 2024-04-29 |
| anyi beauty turmeric vitamin c radiance cream | C200263 | 2024-04-29 |
| anyi beauty vitamin c 20% cream | C200263 | 2024-04-29 |
| anyi beauty vitamin c evens skin tone face serum | C200263 | 2024-04-29 |
| anyi beauty vitamin c face cream | C200263 | 2024-04-29 |
| anyi beauty vitamin c super serum | C200263 | 2024-04-27 |
| aquasol a | New Drug Application | 2020-08-14 |
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Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CA: Vitamin a, plain
— A11CA01: Retinol (vit a)
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD02: Retinol
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX02: Retinol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA02: Retinol
HCPCS
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Clinical
Clinical Trials
6092 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 31 | 47 | 42 | 60 | 253 | 419 |
| Colorectal neoplasms | D015179 | — | — | 75 | 200 | 114 | 4 | 19 | 371 |
| Neoplasms | D009369 | — | C80 | 115 | 69 | 40 | 6 | 21 | 230 |
| Adenocarcinoma | D000230 | — | — | 55 | 100 | 35 | 1 | 5 | 173 |
| Healthy volunteers/patients | — | — | — | 56 | 9 | 2 | 3 | 98 | 166 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 12 | 23 | 47 | 27 | 53 | 158 |
| Syndrome | D013577 | — | — | 20 | 43 | 17 | 14 | 66 | 147 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 13 | 30 | 22 | 13 | 75 | 143 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 8 | 11 | 5 | 16 | 93 | 131 |
| Covid-19 | D000086382 | — | U07.1 | 8 | 31 | 31 | 10 | 52 | 123 |
Show 465 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 62 | 95 | 20 | — | 11 | 161 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 26 | 32 | 12 | — | 23 | 89 |
| Rectal neoplasms | D012004 | — | — | 19 | 54 | 17 | — | 3 | 88 |
| Prostatic neoplasms | D011471 | — | C61 | 13 | 32 | 20 | — | 9 | 68 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 11 | 11 | 8 | — | 2 | 30 |
| Myeloid leukemia | D007951 | — | C92 | 11 | 17 | 2 | — | 1 | 27 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | 1 | 3 | 1 | — | 22 | 26 |
| Pancreatic ductal carcinoma | D021441 | — | — | 15 | 12 | 2 | — | — | 25 |
| Preleukemia | D011289 | — | — | 12 | 13 | 1 | — | 2 | 24 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 6 | 3 | — | 15 | 23 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 13 | 9 | — | — | 1 | 19 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 10 | 11 | — | — | 1 | 19 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | 2 | 1 | — | — | 16 | 18 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 2 | 1 | — | — | 14 | 17 |
| Plasma cell neoplasms | D054219 | — | — | 11 | 9 | — | — | — | 16 |
| Exercise | D015444 | EFO_0000483 | — | — | 1 | — | — | 14 | 15 |
| Chronic pain | D059350 | HP_0012532 | — | — | 4 | — | — | 10 | 14 |
| Triple negative breast neoplasms | D064726 | — | — | 7 | 6 | — | — | 1 | 12 |
| Sarcoma | D012509 | — | — | 4 | 9 | — | — | — | 12 |
| Gastrointestinal microbiome | D000069196 | — | — | 1 | 1 | — | — | 10 | 12 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 9 | — | — | — | 3 | 12 |
| Diet therapy | D004035 | — | — | 1 | — | — | — | 10 | 11 |
| Biological availability | D001682 | — | — | 2 | — | — | — | 5 | 7 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | 5 | 6 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | — | — | — | 5 | 6 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 4 | — | — | — | 1 | 5 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | 1 | — | — | — | 3 | 4 |
| Metaplasia | D008679 | — | — | 1 | — | — | — | 3 | 4 |
| Drug interactions | D004347 | — | — | 4 | — | — | — | — | 4 |
| Hot flashes | D019584 | — | — | 1 | — | — | — | 3 | 4 |
Show 80 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy diet | D000072001 | — | — | — | — | — | — | 19 | 19 |
| Healthy aging | D000073656 | — | — | — | — | — | — | 10 | 10 |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 9 | 9 |
| Nutritional status | D009752 | — | — | — | — | — | — | 8 | 8 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 8 | 8 |
| Body composition | D001823 | — | — | — | — | — | — | 7 | 7 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 7 | 7 |
| Gyrate atrophy | D015799 | — | — | — | — | — | — | 6 | 6 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | — | — | 6 | 6 |
| Hypotrichosis | D007039 | HP_0008070 | — | — | — | — | — | 6 | 6 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retinol |
| INN | retinol |
| Description | Retinol is a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). It has a role as a human metabolite. It is a primary allylic alcohol and a retinoid. |
| Classification | Small molecule |
| Drug class | Vitamin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1 |
Identifiers
| PDB | — |
| CAS-ID | 68-26-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL986 |
| ChEBI ID | 17336 |
| PubChem CID | 1071 |
| DrugBank | DB00162 |
| UNII ID | G2SH0XKK91 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P55093)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,365 adverse events reported
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