Retinol
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitamin A, Vitaped (retinol) is a small molecule pharmaceutical. Retinol was first approved as Aquasol a on 1982-01-01. It is known to target nuclear receptor subfamily 2 group C member 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Aquasol a (discontinued: Afaxin, Alphalin, Aquasol a, Vi-dom-a, Vitamin a)
CombinationsInfuvite, Multiple vitamins injection (discontinued: Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Vitamin a palmitate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AQUASOL A | Casper Pharma | N-006823 RX | 1982-01-01 | 1 products, RLD, RS |
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 5% retinol | C200263 | 2024-10-16 |
| acne relief retinol treatment and moisturizer | OTC monograph final | 2022-02-10 |
| acne wipeout clinical acne system | OTC monograph final | 2020-10-15 |
| advanced retinol moisturizer | C200263 | 2024-10-20 |
| advanced retinol rejuvenating eye cream | C200263 | 2024-11-07 |
| anyi beauty retinol brightening anti aging face cream | C200263 | 2024-04-29 |
| aoao retinol anti-aging box set | C200263 | 2025-01-08 |
| aoao retinol anti-aging eye cream | C200263 | 2024-11-06 |
| aoao retinol anti-aging milk | C200263 | 2024-11-07 |
| aoao retinol anti-aging neck cream | C200263 | 2024-11-07 |
Show 113 more
Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CA: Vitamin a, plain
— A11CA01: Retinol (vit a)
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD02: Retinol
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX02: Retinol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA02: Retinol
HCPCS
No data
Clinical
Clinical Trials
4914 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 31 | 48 | 42 | 64 | 305 | 477 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 11 | 22 | 43 | 25 | 64 | 162 |
| Healthy volunteers/patients | — | — | — | 34 | 8 | 2 | 5 | 92 | 139 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 6 | 12 | 5 | 13 | 102 | 136 |
| Covid-19 | D000086382 | — | U07.1 | 9 | 27 | 29 | 9 | 51 | 118 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | 8 | 14 | 6 | 83 | 109 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 5 | 16 | 14 | 65 | 99 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 8 | 24 | 10 | 10 | 53 | 99 |
| Inflammation | D007249 | MP_0001845 | — | 9 | 14 | 3 | 8 | 58 | 87 |
| Chronic renal insufficiency | D051436 | — | N18 | 7 | 14 | 14 | 22 | 34 | 86 |
Show 410 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 14 | 25 | 10 | — | 27 | 74 |
| Prostatic neoplasms | D011471 | — | C61 | 5 | 19 | 11 | — | 7 | 39 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 16 | 15 | 3 | — | 6 | 38 |
| Cognitive dysfunction | D060825 | — | G31.84 | 4 | 11 | 4 | — | 23 | 38 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 5 | 4 | — | 23 | 31 |
| Oxidative stress | D018384 | EFO_1001905 | — | 2 | 6 | 1 | — | 21 | 29 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | 3 | 1 | — | 16 | 23 |
| Frailty | D000073496 | — | R53.1 | 1 | 5 | 2 | — | 17 | 22 |
| Growth disorders | D006130 | — | — | — | 2 | 5 | — | 16 | 21 |
| Myeloid leukemia | D007951 | — | C92 | 6 | 10 | 7 | — | 1 | 20 |
Show 288 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 12 | 10 | — | — | 1 | 17 |
| Exercise | D015444 | EFO_0000483 | — | — | 1 | — | — | 14 | 15 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 2 | 2 | — | — | 11 | 15 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 5 | 1 | — | — | 8 | 14 |
| Gastrointestinal microbiome | D000069196 | — | — | 1 | 1 | — | — | 11 | 13 |
| Gestational diabetes | D016640 | — | O24.4 | 2 | 1 | — | — | 11 | 13 |
| Hypercholesterolemia | D006937 | — | — | 1 | 2 | — | — | 10 | 13 |
| Dementia | D003704 | EFO_0003862 | F03 | 4 | 3 | — | — | 6 | 12 |
| Feeding behavior | D005247 | — | — | 1 | 1 | — | — | 10 | 12 |
| Ascorbic acid deficiency | D001206 | EFO_1000822 | E54 | 1 | 2 | — | — | 9 | 12 |
Show 264 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diet therapy | D004035 | — | — | 1 | — | — | — | 10 | 11 |
| Morbid obesity | D009767 | EFO_0001074 | — | 2 | — | — | — | 7 | 9 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | 7 | 8 |
| Gingivitis | D005891 | — | K05.10 | 1 | — | — | — | 5 | 6 |
| Biological availability | D001682 | — | — | 1 | — | — | — | 5 | 6 |
| Dysmenorrhea | D004412 | — | N94.6 | 1 | — | — | — | 5 | 6 |
| Hot flashes | D019584 | — | — | 1 | — | — | — | 4 | 5 |
| Sedentary behavior | D057185 | — | — | 1 | — | — | — | 4 | 5 |
| Cardiac surgical procedures | D006348 | — | — | 1 | — | — | — | 4 | 5 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | — | — | — | 4 | 5 |
Show 80 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy diet | D000072001 | — | — | — | — | — | — | 21 | 21 |
| Nutritional status | D009752 | — | — | — | — | — | — | 11 | 11 |
| Healthy aging | D000073656 | — | — | — | — | — | — | 11 | 11 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 10 | 10 |
| Folic acid deficiency | D005494 | EFO_0001070 | E53.8 | — | — | — | — | 10 | 10 |
| Phenylketonurias | D010661 | — | E70.0 | — | — | — | — | 10 | 10 |
| Deglutition disorders | D003680 | — | R13.1 | — | — | — | — | 10 | 10 |
| Behavior | D001519 | GO_0007610 | STY/T053 | — | — | — | — | 8 | 8 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 8 | 8 |
| Nutrition disorders | D009748 | EFO_0001069 | — | — | — | — | — | 7 | 7 |
Show 528 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retinol |
| INN | retinol |
| Description | Retinol is a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). It has a role as a human metabolite. It is a primary allylic alcohol and a retinoid. |
| Classification | Small molecule |
| Drug class | Vitamin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1 |
Identifiers
| PDB | — |
| CAS-ID | 68-26-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL986 |
| ChEBI ID | 17336 |
| PubChem CID | 1071 |
| DrugBank | DB00162 |
| UNII ID | G2SH0XKK91 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P55093)
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
Black-box warning for: Prenatal plus multivitamin plus dha minicaps
Adverse Events
Top Adverse Reactions
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1,474 adverse events reported
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